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doi: 10.3389/fimmu.2018.02069 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Zhang Y, Duan K

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Immuno-oncology advances are propelled by three paradigm-shifting modalitiesimmune checkpoint disruption (anti-PD-1/CTLA-4) to reverse T-cell exhaustion, genetically engineered CAR-T cells targeting CD19/BCMA for tumor-specific cytotoxicity, and dendritic cell vaccines loaded with neoantigens to prime antigen-presenting cellswhich collectively overcome tumor immune evasion mechanisms, achieving durable remission rates exceeding 50% in refractory lymphomas (NCT02348216)

Although mitochondria have long been recognized as key regulators of host cell homeostasis, their role in antifungal immunity and fungal pathogenesis is gaining increasing attention

Another study showed that Astragaloside IV increased ATP content, stimulated nuclear translocation of -Catenin, accelerated epithelial cell proliferation, improved the destruction of actin filaments, inhibited degradation of claudin-5 and occludin, which can effectively reduce the extent of damage to the colonic mucosa (Jiang et al., 2017)

Treatment effects were greatest in the first year after randomization when the doses of i.v