glutathione and warfarin Characterization of Inhibition Kinetics Requires Stabilization of Intramembrane Vitamin K Epoxide Reductases A genome-wide CRISPR-Cas9 knockout screen

A genome wide CRISPR Cas9 knockout screen identifies FSP1 as the warfarin resistant vitamin K reductase Nature Communications Anticoagulant medications help prevent thrombi, or blood clots from forming. They work by interfering with the normal function of proteins called clotting factors in the coagulation cascade. While common anticoagulants like warfarin Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation Science Warfarin Pathway, Pharmacokinetics The pharmacogenetics of warfarin in clinical practice Biochemia Medica Structural and cellular basis of vitamin K antagonism ScienceDirect

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