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Bedside sensory tests are operator-dependent tests that tend to diagnose DPN when it is already well-established, while their implementation is challenging by general practitioners or at busy diabetes clinics given the time constraints (28, 63, 80)

For example, agents (including compositions and pharmaceutical formulations) encompassed by the present invention can modulate the copy number, amount, and/or activity of a biomarker (e.g., at least one target listed in table 1, table 2, examples, etc.) to thereby modulate the inflammatory phenotype of monocytes and/or macrophages and further modulate the immune response

Looking ahead, patients will be better informed, encouraged to provide feedback, and closely monitored to optimize therapeutic results

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Interestingly, a recent study suggests significant reduction of MCT1 in peripheral myelin of periaxin-deficient mice, which is a model of inherited Charcot-Marie-Tooth 4F peripheral neuropathy (Siems et al., 2020)

and inhibits cisplatin-induced apoptosis in HEI-OC1 cells ( 3.1.6 Rutin Rutin belongs to the vitamin P family and is a natural flavonol glycoside