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However, during aging, this balance between the processes for synthesis and consumption of NAD+ can shift, and NAD+ degradation can outpace the ability of cells to make NAD+ de novo or their ability to recycle or salvage NAM effectively

Ganguly R, Hasanally D, Stamenkovic A, Maddaford TG, Chaudhary R, Pierce GN, et al

10.1161/01.atv.17.10.2245 203 McCabeT

[DOI] [PMC free article] [PubMed] [Google Scholar] [60].Weiss N, Zhang YY, Heydrick S, Bierl C, Loscalzo J, Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction

Thus, extracellular glutathione can be cleaved yielding amino acids that are capable of penetrating inside the cell, where they can be used for the synthesis of a new GSH molecule

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