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Safety, efficacy and tumor mutational burden as a biomarker of overall survival benefit in chemo-refractory gastric cancer treated with toripalimab, a PD-1 antibody in phase ib/ii clinical trial NCT02915432

These findings indicate a proximal obstruction of the urinary tract leading to urinary stasis and subsequent infections, specifically localizing the defect to the ureteropelvic junction

A considerable improvement in the outcomes of patients with SARS-CoV-2 infection may be achieved by downregulating the innate immune response and reducing the inflammatory reaction

Conclusions: Although GPX3 may not directly influence immune checkpoint pathways, its high expression in myeloid cells and fibroblasts suggests that it might indirectly modulate immune responses by regulating the tumor microenvironment

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Carlo-Stella N, Badulli C, De Silvestri A, Bazzichi L, Martinetti M, Lorusso L, et al