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Similarly, the HMOX2 C265A mutant, which cannot bind haem to its haem regulatory motif (HRM), and the HMOX2 K68R mutant, which is not ubiquitinated by MITOL, also exhibited reduced IFP2.0 signals compared to HMOX2 WT (Fig

These hINPC lines exhibited increased proliferation, and KIAA1549-BRAF -expressing hINPCs had increased MAPK pathway activation (68)

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