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High-frequency monitoring for early detection of cisplatin ototoxicity

NGRA aims to conduct safety assessments that are human-relevant, exposure-led, hypothesis-driven and designed to prevent harm ( in vitro bioactivity at human-relevant concentrations and, consequently, adverse health effects, in lieu of replicating apical endpoints that would traditionally be obtained using high-dose animal studies (Thomas et al., 2019)

This indicated that the increased CYSS levels might originate from auto-oxidation of CYS, which easily takes place out of the cell under normoxic conditions (47)

Wong G, Wu SY, Chen WM, Hsu PJ, Chou TC, Chiang MF, Wu MS, Lee MC, Soong RS (2024) Effects of N-acetylcysteine on hepatocellular carcinoma in chronic hepatitis C

It plays a critical role in the electron transport chain within mitochondria, facilitating adenosine triphosphate (ATP) productionthe primary energy currency of cells