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Further studies including large-scale, controlled trials of existing and new treatments are pertinent for enhancing our understanding in this field

While RCTs minimize bias and provide strong causal inference, they are not always the most logical or practical choice

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One possible caveat with procedure B is that in the absence of IAM/IAM-TPP as a capping agent, extended exposure to TCEP could sequester internal sulfane sulfur atoms as TCEP = S 44 through nucleophilic attack on the internal sulfur atom (Supplementary Fig

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