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Mood changes, including depression or irritability, can also be related to low B12 levels

Berlin: Springer (2015)

Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain.This drug is not approved for use in children younger than 2 years due to an increased risk of side effects (such as slow/shallow breathing)

For those with some of the above described issues, neural prolotherapy may prove to be a safe and effective treatment option for trigeminal neuralgia

Patients on long-term PPIs should have their B12 status monitored periodically, particularly if other risk factors are present