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Description

Site-directed mutagenesis was performed using Phusion DNA polymerase (NEB)

grant COSMIT 2015-0451), Brazilian National Counsel of Technological and Scientific Development (CnPQ), CAPES-COFECUB, CELLOMET and INSERM

This approach led to restoring p53 expression, sensitizing tumors to sirolimus, and strong antitumor effect in various preclinical HCC and NSCLC models (92)