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A study generated a new suicide gene/prodrug system showed that specific cancer cells modified to express Tb HGPRT were able to convert the non-toxic allopurinol into cytotoxic metabolites, selectively induced apoptosis in five NSCLC cell lines, one murine lung cancer cell line (M27), and four human NSCLC cell lines (A549, H460, H661, H520)

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Stress tolerance assay in yeast cells Wild type cells of yeast strain BY4741 and mutants of MG detoxification enzymes i.e., GLYI mutant BY4741 cells (GLYIKO), GLYII mutant BY4741cells (GLYIIKO) and D-LDH mutant BY4741 cells (D-LDHKO) were transformed with empty vector pYES2

10.1126/scitranslmed.adg3451 52 CourtM

As a naturally occurring peptide fragment, BPC-157 also lacks strong patent protection, which has likely reduced commercial incentive to fund the trials needed for FDA approval