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Description

These safety differences stem from AOD-9604s mechanism as a C-terminal fragment lacking affinity for the traditional growth hormone receptor

doi:10.1073/pnas.1424254112

Predictive models for BBB permeability are based on the rate and extent of brain penetration (respectively log PS and log BB) constants, built using non-linear least squares regression validated by an internal validation set, and two other experimental external validation sets 109,110