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Gimsing, J.L

It is often referred to as the master antioxidant because of its critical role in protecting cells from damage caused by oxidative stress , supporting the immune system, and promoting detoxification

Melatonin, for example, has been demonstrated to prevent osteoblast ferroptosis through the activation of the Nrf2/HO-1 signaling pathway, thereby enhancing bone microstructure in both in vivo and in vitro studies ( 2+ , ROS and MDA levels, as well as a decrease in GPX4 and GSH levels ( in vitro demonstrated that metformin inhibits osteoblast ferroptosis induced by high glucose and palmitic acid, significantly enhances the expression of ferroptosis protective proteins (GPX4, FTH1, SLC7A11), and reduces lipid peroxidation products and iron ion levels

(2014, Journal of Psychopharmacology ) gave healthy adults a single oral dose of 4 mg/kg, showing enhanced memory and brain connectivity with no acute adverse effects, however this was not a long term study of daily dosage

N.BrannstromM.et al (2021)

The antioxidant paradox is a term introduced by Halliwell et al., highlighting a potential downside to the excessive use of antioxidant regimens [215]