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Consequently, this review will not address them in detail, focusing instead on biomarkers with broader relevance to assess neuroprotection

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Acknowledgements We would like to thank the Kyoto Integrated Science & Technology Bio-Analysis Center for allowing us to use their LC-MS/MS (3200 QTRAP) and Editage (www.editage.jp) for English language editing

Of these 10 studies, 1 was an open trial, which was considered of moderate quality, and the remaining studies were randomised controlled trials, all of high quality ( Table 2 )

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