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(2022) 8(16):eabm8011

Abbreviations SSP: Serine synthesis pathway PTM: Post-translational modification PHGDH: Phosphoglycerate dehydrogenase PSAT1: Phosphoserine aminotransferase 1 PSPH: Phosphoserine phosphatase GSH: Glutathione SAM: S-adenosylmethionine 3-PG: 3-Phosphoglycerate 3-PHP: 3-Phosphohydroxypyruvate NAD + : Nicotinamide adenine dinucleotide NADH: Reduced nicotinamide adenine dinucleotide 3-PS: 3-Phosphoserine -KG: -Ketoglutarate PSPH: Phosphoserine phosphatase SHMT1/2: Serine hydroxymethyltransferase 1/2 SBD: Substrate-binding domain NBD: Nucleotide-binding domain ASBD: Allosteric substrate-binding domain ACTD: Aspartate kinase-chorismate mutase-TyrA domain ATP: Adenosine triphosphate ROS: Reactive oxygen species AMPK: AMP-activated protein kinase GSK3: Glycogen synthase kinase-3 beta GSK3: Inhibitor CHIR SGOC: SerineGlycineOneCarbon SYK: Spleen tyrosine kinase NADP + : Nicotinamide adenine dinucleotide phosphate NADPH: Reduced nicotinamide adenine dinucleotide phosphate eIF3f: Eukaryotic translation initiation factor 3 subunit f DDB1: DNA damage-binding protein 1 IDH1: Isocitrate dehydrogenase 1 NSCLC: Non-small cell lung cancer P4HB: Prolyl 4hydroxylase subunit beta ASS1: Argininosuccinate synthase TNBC: Triple-negative breast cancer UCHL3: Ubiquitin carboxyl terminal hydrolase L3 HCC: Hepatocellular carcinoma CSC: Cancer stem cell LUAD: Lung adenocarcinoma JOSD2: Josephin Domain-containing 2 CSFV: Classical swine fever virus PRMT1: Protein arginine methyltransferase-1 KATs: Lysine acetyltransferases HDAC: Histone deacetylases SIRT: NAD + -dependent sirtuins PATs: Palmitoyl acyltransferases FASN: Fatty acid synthase Prdx6: Peroxiredoxin 6 GSNO: S-nitroso-glutathione PFAS: Phosphoribosylformylglycinamidine synthase SUMO: Small ubiquitin-like modifier LLO: Listeriolysin O Glo2: Glyoxalase 2 LGSH: Lactylglutathione RAB11A: Ras-related protein in brain 11A UBE4B: Ubiquitination factor E4B USP14: Ubiquitin-specific protease 14 Kme1: Mono-methyllysine BPGM: Bisphosphoglycerate mutase PGAM1: Phosphoglycerate mutase DRP1: Dynamin-related protein 1 CREB: Cyclic AMP response element-binding protein LKB1: Liver kinase B1 PGK1: Phosphoglycerate kinase 1 PKM2: Pyruvate kinase M2 SK1: Sphingosine kinase 1 PIMT: Protein L-IsoAsp methyltransferase NRF2: Nuclear erythroid-related factor-2 IGF2BP3: Insulin-like growth factor 2 mRNA-binding protein 3 References Kelly B, Pearce EL