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For example, the neurotoxin models of PD (using MPTP or 6-OHDA) recapitulate features of the diseaseelevated -synuclein, astrocyte activation, bloodbrain barrier disruption, inflammation, oxidative stress, and dopaminergic neuron lossand these models have demonstrated the neuroprotective potential of various dietary polyphenols (10)

2b), consistent with the association between the stability of these proteins and the fidelity of Fe-S cluster synthesis 41

It was first described in 1906 by Harden and Young as a cell component that enhanced alcohol fermentation in yeast [4]

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Additionally, co-administration with hepatoprotective agents, such as silymarin, could help mitigate potential liver toxicity at higher doses

Brundu S, Palma L, Picceri GG, Ligi D, Orlandi C, Galluzzi L, Chiarantini L, Casabianca A, Schiavano GF, Santi M, Mannello F, Green K, Smietana M, Magnani M, Fraternale A