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In addition, the authors reported minimal stimulation and highly effective treatment of DED by LCTG in animal models

Chlorogenic acid was administered intraperitoneally at doses of 2.5, 5, and 10 mg/kg on two occasions: 10 min before ischemia and 10 min before reperfusion

Docking interactions Glutathione reductase was used as a binding enzyme to virtually investigate the potential of the selected compounds as antioxidants

Key metrics include mtDNA copy number (reflecting depletion), mtDNA deletion frequency measured through long-fragment PCR or digital PCR, and levels of oxidized mtDNA bases like 8-oxo-dG ( 6 Clinical relevance and translational potential of mtDNA monitoring The growing understanding of mtDNAs role in HIV pathogenesis and ART-related toxicity has stimulated interest in its value as a clinically actionable biomarker