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This suggests that CaOx-exo exacerbates pre-existing renal injury caused by kidney stones, potentially through enhanced macrophage phagocytosis or upregulated expression of scavenger receptors, thereby increasing the uptake of exogenous exosomes [32]

Liver histology for fibrosis by Ishak score was assessed, blinded to LSM

Abbreviations GSVs GLUT4-storage vesicles PM plasma membrane TIRFM total internal reflection fluorescence microscopy Competing Interests The authors declare that there are no competing interests associated with the manuscript

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Homocysteine accumulates in the blood, causing vascular damage and micro-clotting, while downstream glutathione synthesis grinds to a halt