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IGF1 can reduce blood glucose levels and has been used to treat patients with type 1 and 2 diabetes This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

3.2 Metalloproteinase Tamoxifen successfully up-regulated expression of metalloproteinases-1, TIMP-1, and down-regulated expression of matrix metalloproteinase 9, MMP-9

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Mice with a deficiency of key components in the NF-B pathway die as a result of massive hepatocyte apoptosis induced by TNF 37,38 , supporting the critical role of maintenance of hepatocyte NF-B pathway in protecting against TNF cytotoxicity