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It was demonstrated that cysteine S -conjugate -lyase highly expressed in the kidney was responsible for the observed nephrotoxicity (Zhang and Hanigan, 2003

In vivo, improved cartilage repair was achieved by articular injection of MSCs with high levels of cellular GSH and MSCs cultured under high-density conditions, as confirmed by Collagen type 2 IHC, Safranin-O staining and ODriscoll scores showing that more hyaline cartilage was formed on the defects

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