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While low concentrations of ROS have positive effects on cell signaling, proliferation, differentiation, and apoptosis, higher concentrations of ROS contribute to the pathophysiology of a number of chronic and degenerative diseases [40]

Jul 9 2021 Avdeev et al., Journal of Infection, doi:10.1016/j.jinf.2021.07.003 N-acetylcysteine for the treatment of COVID-19 among hospitalized patients 69% lower mortality (p=0.34) , 77% lower ventilation (p=0.18) , 77% lower ICU admission (p=0.18) , and 15% shorter hospitalization (p=0.01)

Biochim Biophys Acta Rev Cancer 1878(3):188890

J Neurosci 2003;23:10756-64

Nat Commun 16 , 3748 (2025)

Most efficacy claims in the literature derive from animal experiments and in vitro work