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Following this treatment plan helps doctors manage severe vitamin B12 deficiency in adults

Further interventional studies conducted on humans are needed to clear the causal relationship between T1D and intestinal microbiota [60]

Factorial Approach Researchers have attempted to determine B12 needs by measuring daily B12 body losses, also known as the factorial approach

I have also been experiencing extreme fatigue

The latter in response to stimulation by intestinal microbial antigens, particularly LPS, upregulate the production of proinflammatory cytokines (e.g., IL-1, IL-6, TNF) and reactive oxygen species (ROS), contributing to the enhancement of pro-inflammatory reactions (Hine and Loke, 2020)