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It is crucial to identify the core targets that lead to pathological changes from quantitative to qualitative changes during this process, and the above preventive interventions, sleep improvement, physical exercise, dietary regulation, and social intervention, may prolong or reverse the subclinical pathological stage (Fig

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Ko et al., 2014), have all been demonstrated to be capable of inducing immunogenic responses, while necrosis can in fact contribute to a chronic inflammatory microenvironment that is protumourigenic and immunosuppressive (Vakkila and Lotze, 2004)