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20 Even in the absence of a positive family history, germline mutations in genes associated with pancreatic cancer were identified in 31 of 854 (3.6%) patients who underwent surgical resection for pancreatic cancer

Jayaram-Lindstrom, N., Hammarberg, A., Beck, O., et al

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Cell Mol Gastroenterol Hepatol

Emerging evidence suggests that inflammatory stimuli [7], dysregulation of the ubiquitin-proteasome system [8], and disturbances in immune modulation [9] play key roles in its development