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While compounding pharmacies can "undoubtedly make better versions of these peptides," UC Davis' Knoepfler says, that doesn't resolve concerns that peptides, especially if taken at the wrong dose, could inadvertently promote cancer growth or trigger a dangerous immune response

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Conditional knockout studies further indicate opposing roles for myeloid HIF-1 and HIF-2 in DSS colitis, where HIF-1 deficiency ameliorates inflammation but HIF-2 deficiency worsens disease (78)

Thus, Nrf2 may become a potential therapeutic target