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By synthesizing a molecule that could permeate the cell membrane and selectively inhibit NNMT, researchers discovered they could fundamentally alter the metabolic profile of the cell

I think that is pretty promising, says Lucas, the studys corresponding author

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Therefore, inhibition of hyperactivated mTOR may represent promising therapeutic targets for AD (Cassano and Magini 2019).Similarly, in the pathogenesis of MS, peripheral immune cells penetrate the BBB into the brain and destroy myelin membranes and neurons (Alavi and Fanoudi 2023)

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Its the difference between clean data and a confounded experiment