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KDIGO defines initial hyporesponsiveness as having no increase in hemoglobin concentration after the first month of appropriate weight-based dosing, and acquired hyporesponsiveness as requiring two increases in ESA doses up to 50 percent beyond the dose at which the patient had originally been stable

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doi: 10.1007/s00299-006-0212-8 76 ZechmannB.ZellnigG.MllerM

While it is widely available through peptide suppliers, it lacks the standardized testing, safety oversight, and regulatory approval associated with conventional medications or supplements