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High levels of dopamine metabolism, iron, and calcium, coupled with mitochondrial dysfunction and neuroinflammation, contribute to the excessive production of ROS in the brains of PD patients (183)

Free radical-mediated damages of lipids, proteins, and nucleic acids are seen during enhanced OS

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Per BNF and BSH guidance: For confirmed deficiency without neurological involvement: 1 mg IM on alternate days for two weeks, then 1 mg every two to three months for maintenance

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doi: 10.3389/fnut.2023.1068343 Received 12 October 2022 Accepted 21 March 2023 Published 05 April 2023 Volume 10 - 2023 Edited by Andrew Scholey, Monash University, Australia Reviewed by Jessica Zuiga-Hernandez, University of Talca, Chile