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In another randomized controlled trial, 57 subjects with episodic migraine received either 1,000 IU (25 mcg) vitamin D3 plus the cholesterol-lowering drug simvastatin (Zocor) or placebo for 24 weeks

Another research including 111 families, demonstrated that deficient MTHFR enzyme activity in pregnant women was related to the A1298C variant, which was associated with a higher risk of schizophrenia in the offsprings 60

Some report improvement in pain or mobility within a few weeks

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Studies have examined NNMT inhibition in preclinical systems involving energy balance, adipocyte biology, and NAD related chemistry