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doi: 10.1152/physrev.00040.2012

GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues

While ROS scavenging is beneficial in chronic diseases like diabetes (Zhang et al., 2020), excessive antioxidant supplementation may disrupt redox homeostasis, as evidenced by increased cancer risk in vitamin E trials (Poprac et al., 2017)

While glutathione is widely known for protecting cells from damage, the team found that cancer cells can hijack it and use it as a nutrient, particularly in environments where other resources are scarce

Naltrexone effects are similar to methadones

patients are required to meet clinical criteria and often undergo lengthy testing to exclude other conditions, a process that is often prolonged, costly, and burdensome for patients