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Neural Regen Res 7:10291039 Tsiklauri N, Pirkulashvili N, Nozadze I, Nebieridze M, Gurtskaia G, Abzianidze E, Tsagareli MG (2018) Antinociceptive tolerance to NSAIDs in the anterior cingulate cortex is mediated via endogenous opioid mechanism