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Moreover, it has also been observed that both the numbers and the differentiation stages of OPCs and mature oligodendrocytes are highly variable within lesions of different patients and in different lesion stages

C57BL/6J mice were fed a normal diet (control group) or an HFHC diet (HFHC group) for 24 weeks

The significant upregulation of MAP3K6 expression may have imposed some neurotoxicity and likely contributed to the premature death of treated mice and would be considered an unintended adverse event with long-term CK1/-specific PF-05236216 inhibitor treatment

Tayran H, Yilmaz E, Bhattarai P et al (2024a) ABCA7dependent neuropeptideY signalling is a resilience mechanism required for synaptic integrity in Alzheimers disease

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