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Food cravings have also been found to be stimulated by UPF consumption (88, 126, 131)

However, epinephrine itself could have cardiovascular effects 23

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In humans, the number of synapses per SNc dopaminergic neuron increases tenfold, reaching between 1 and 2.4 million synapses (Bolam & Pissadaki, 2012

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and in terms of vascular barrier function, the loss of HS exposes adhesion molecules, promoting the adhesion of leukocytes and platelets, triggering inflammation and thrombosis, and further impairing renal blood supply and glomerular filtration, ultimately leading to a decrease in GFR (100)