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Checkpoints in TNF-induced cell death: implications in inflammation and cancer

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Rathore, P

Its known to trigger a cascade of responses within the skin, encouraging the synthesis of key proteins in the extracellular matrix, including collagen, elastin, and glycosaminoglycans

Those are what make breaks the sensible default, not a tolerance story borrowed from receptor-based compounds

But it must be interpreted with caution: without a control arm, we cannot exclude that this profile simply marks patients who would have improved with optimal standard care alone