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The FDA moved these peptides to Category 2 primarily due to a lack of large-scale, randomized, placebo-controlled human trials demonstrating their safety and efficacy

Notably, no additional diffraction peaks associated with silver oxide (Ag 2 O) were detected, suggesting that polyphenolic compounds present in the plant extract effectively inhibit the oxidation of Ag nanoparticles during synthesis 31

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(2007) published in the New England Journal of Medicine and subsequent work by Stanley et al