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Because safety hasn't been established, the standard advice is to skip it while pregnant or nursing unless a doctor says otherwise (WebMD)

Superoxide radical production stimulates retroocular fibroblast proliferation in Graves ophthalmopathy

& Gutteridge, J

showed that Gstm1 KO mice displayed augmented kidney injury and inflammation, compared to wild-type mice

BaP acts through suppressing the Nrf2/HO-1 pathway, resulting in a significant reduction of the antioxidant enzyme activities and a marked elevation of lipid peroxidation, cortisol, and proinflammatory cytokine levels, which subsequently lead to notable pathological changes in the hepatic, branchial, and intestinal tissues