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The authors found that the combination of ACR, MVK and CPO at their sublethal doses induces expression of proinflammatory cytokines, such as interleukin (IL)-6 and IL-1, oxidative stress, mitochondrial damage, DNA damage response and cytosolic accumulation of nuclear and mitochondrial DNA in human umbilical vein endothelial cells (HUVECs), whereas ACR, MVK or CPO alone causes only DNA damage response without the increase in cytosolic DNA fragments

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Effect of cannabinoids on exosomes and microvesicles released in prostate cancer Microvesicles may carry caspase-3 away from cells as a protective mechanism against apoptosis

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