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Enzymatic and antioxidant effects observed in vivo and predicted by docking for AECS are consistent with those reported for each BC, identified by HPLC-QTOF-MS analysis, such as ellagic acid, which has been proposed to upregulate expression and activity of antioxidant enzymes (SOD, glutathione reductase, GPx, catalase) in murine models (Reference Mishra and Vinayak59)

Nithyananthan S, Thirunavukkarasu C (2019) Chemotherapeutic doses of arsenic trioxide delays hepatic regeneration by oxidative stress and hepatocyte apoptosis in partial hepatectomy rat

however, the specific role of this modification in the human body remains unclear 37,61,62

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If nausea, vomiting, or diarrhea remain significant at any dose, hold that dose for an additional two to four weeks before escalating

Shen, John G