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The classic histologic findings in DM skin biopsies include vacuolar interface dermatitis with keratinocyte dyskeratosis, increased reticular dermal mucin, superficial dermal vascular dilatation, and variably dense perivascular lymphohistiocytic inflammation (Figure 4A and B)

While TIR offers a slight improvement in these adverse effects, its co-administration with DXN does not significantly counteract them

After each increase, blood levels peak over 24 to 72 hours, when nausea and fullness are most likely to return. These effects usually ease during the four-week hold