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While short-term use may cause only transient effects, prolonged supraphysiological IGF-1 receptor activation could potentially cause unwanted tissue growth including cardiac hypertrophy, which at extreme levels could impair cardiac function, and growth of other organs

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(112) identified 20 human studies that examined garlic intake in relation to gastric cancer risk: three intervention studies, one case-cohort study, 13 case-control studies, and three cross-sectional/ecologic studies