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6 , e1000908 (2010)

In fact, circulating MOTS-c levels are shown to increase with exercise and, much like GHK-Cu and other endogenous peptides, natural levels of MOTS-c tend to decrease with age, and for this reason it has gained interest in the field of aging research

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Physician-prescribed topical formulations deliver the peptide exactly where the benefits occur, at therapeutic concentrations (2 to 10 percent or more), without systemic distribution