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Tail-vein injection of parental, control and Grpr -expressing cells demonstrated that GRPR expression alone is sufficient to promote lung metastasis (Fig

32,33 This refers to homozygous versus heterozygous genetic pairing of alleles, the former indicating two identical mutant alleles and the latter indicating a mutant and a normal allele

10.1038/s41598-023-48701-5 4

From day 5 onward, all DSS-treated groups exhibited significant weight loss compared with the NC group, with the most severe reduction observed in the DSS model group

Systematic identification of variant-specific RNA structure-small molecule interactions exemplified by RNA G-quadruplexes

Furthermore, some researchers have used nano-cascade engineering to construct metal-organic supermolecules with p53-activating peptides and CeO 2 nanoparticles, which can activate the p53 signaling pathway and down-regulate the downstream gene GPX4 in vitro and in vivo, thereby inhibiting the development and progression of lung cancer [106]