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doi: 10.1016/j.drudis.2020.07.002 50 SmithC.CortesR.GomezL

With age-related declines in self-synthesis, glutathione levels start deteriorating around the age of 45 and drop more rapidly after 60 [5][6]

This review synthesizes evidence that probiotics mitigate UC through multiple synergistic mechanisms: competitive exclusion to rebalance the microbiota, upregulation of tight junction proteins to restore the intestinal barrier, and bidirectional immunomodulation to restrain excessive inflammation