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The following represents a theoretical ultra-conservative approach based on monotherapy principles: Hypothetical Ultra-Conservative Schedule: This extended 24-week titration period doubles the typical monotherapy escalation timeline , reflecting the complete absence of interaction data and the overlapping side effect profiles

Detection was performed using a UV detector at 220 nm

While sodium thiosulfate may be sufficient alone in mild to moderately severe cases, it should be administered with other antidotes in cases of severe poisoning

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[1] The consequences of untreated deficiency far outweigh the inconvenience of mild, manageable gastrointestinal symptoms

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