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[ [PMID: 26481148]

458 While five cases of grade 3 toxicity were observed (including anorexia, increased serum aspartate aminotransferase, increased serum alkaline phosphatase, fever, and fatigue), no dose-limiting toxicities were reported

Moreover, it has also been shown that TdNs can interfere in the ischemic cascade that involves excitotoxicity, apoptosis, and oxidative stress, and confer neuroprotection to the neuronal SH-SY5Y cells