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In previous studies, cellular senescence has been considered a mechanism of preventing abnormal proliferation to malignancy in keloids and could be used to halt the progression of keloids 13

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The total respiratory exchange ratio (RER) increased considerably and recovered significantly after Mito-Q administration, although there was no discernible difference in oxygen consumption (VO 2 ) and carbon dioxide production (VCO 2 ) (Fig

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The external adverse elements, such as cigarette smoking, physical damage, and microbiota influence, may cause keratinocytes damaged through excessive production of ROS(Plenkowska et al., 2020)