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while preclinical models consistently demonstrate robust tumor suppression, outcomes in human clinical trials have been more modest, largely attributed to rapid systemic elimination and insufficient tissue accumulation within the gastric mucosa

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In animal studies, in comparison to a control diet, HFD consumption resulted in increased hepatic IKK--SSG formation, leading to suppressed IKK- activation and subsequent NF-B suppression

This leads to defective T cell maturation and impaired effector function, resulting in fewer circulating T cells (91)

Sulfonated nonsaccharide heparin mimetics are potent and noncompetitive inhibitors of human neutrophil elastase