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Some experimental studies have reported that UA stimulates the synthesis of proinflammatory cytokines such as IL-1 beta, IL-6, IL-8, and TNF-alpha

[DOI] [PubMed] 104.Jones AL, Simpson KJ

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IGF-1 Receptor (IGF-1R) Activation IGF-1 LR3 binds to and activates the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase expressed on virtually all mammalian cell types