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Plotnikoff GA, Dobberstein L, Raatz S

TNF- can induce the proliferation of fibroblast-like synoviocytes (FLS) and synovial cells by activating nuclear factor kappa-B (NF-B) and extracellular regulated protein kinases (Erk)-1/2-E26 transformation-specific (ETS)-1 signaling pathway, respectively (70, 71), resulting in the secretion of a variety of inflammatory mediators like IL-6, matrix metalloproteinases (MMP)-1, and MMP-3 to increase inflammation (72)

Many people will finally be diagnosed with Hashimotos at this point, but their Hashimotos symptoms may be in more advanced stages, as it may have taken years before abnormal thyroid antibody and thyroid hormone levels appear in lab results

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Waki, K

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