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2.3.1 Dolor: neuropathic pain SR-L1 (known as LRP-1 or CD91), plays a major role in neuroinflammation, nerve de- and re-generation, and neuropathic pain (172, 173)

Mitochondrial Protection Mitochondrial pools of glutathione play a critical role in maintaining mitochondrial integrity, membrane potential, and oxidative balance , making GSH essential in studies of cellular energy metabolism and oxidative stress

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Consistent with an induction of oxidative stress condition, metformin increased mRNA levels of the master redox transcription factor Nrf-2 (nuclear factor erythroid-derived 2-like), as well as transsulfuration enzymes cystathionine beta-synthase and cystathionase and GSH synthesis enzymes -glutamylcysteine synthetase and glutathione synthetase